The structure of an archaeal viral integrase reveals an evolutionarily 1 conserved catalytic core , yet supports a mechanism of DNA cleavage in trans * 2 3 Brian
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75 words 10 Body Text: 1515 words 11 *Corresponding Author: 12 Martin Lawrence 13 Department of Chemistry and Biochemistry, 103 CBB 14 Montana State University 15 Bozeman, MT 59717 16 Phone: (406) 994-5382 17 Fax: (406) 994-5407 18 E-mail: [email protected] 19 20 * Supported by the National Science Foundation (MCB-0920312). Portions of this research 21 were carried out at the Stanford Synchrotron Radiation Laboratory. 22 23 24 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.00547-12 JVI Accepts, published online ahead of print on 16 May 2012 on A uust 0, 2017 by gest http/jvi.asm .rg/ D ow nladed fom
منابع مشابه
The structure of an archaeal viral integrase reveals an evolutionarily conserved catalytic core yet supports a mechanism of DNA cleavage in trans.
The first structure of a catalytic domain from a hyperthermophilic archaeal viral integrase reveals a minimal fold similar to that of bacterial HP1 integrase and defines structural elements conserved across three domains of life. However, structural superposition on bacterial Holliday junction complexes and similarities in the C-terminal tail with that of eukaryotic Flp suggest that the catalyt...
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تاریخ انتشار 2012